Iron dictates the growth, biofilm formation, and virulence of Pseudomonas aeruginosa in pulmonary infections
Our findings indicate that environmental iron facilitates the growth and biofilm formation of <i>P. aeruginosa</i> causing pulmonary infections, while attenuating its virulence. This iron-mediated adaptation may be associated with the persistence of <i>P. aeruginosa</i> pulmonary infections, and these findings merit further investigation.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0003-0425-2718)
- Chen Ruan (ORCID: https://orcid.org/0009-0008-5844-5092)
- Chen Sy
- Shenghua Zou
- Chenshuo Luo
- Chao An
- Yulan Lin
- Baijian Wu
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fuzhou Pulmonary Hospital of Fujian (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fmicb.2025.1742683
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China