Depression, anxiety, and post-traumatic stress disorder in association with cardiovascular disease among patients with systemic lupus erythematosus and rheumatoid arthritis in the All of Us Research Program

In this large US cohort, patients with RA/SLE and mental health conditions had the highest CVD risks compared to those with either condition or none. Strategies are needed to address mental health conditions that contribute to excess CVD risk for patients with RA/SLE. Key points • Patients with RA/SLE and mental health conditions had the highest CVD incidence, compared to those with either RA/SLE or any of the mental health conditions alone. • Adjustment for sociodemographic factors and comorbidities attenuated this relative CVD risk. • No significant interactions were found between RA/SLE and mental health conditions influencing observed CVD risks.