Transcriptomic Analysis in a Model of Aniridia-Associated Keratopathy for Target Discovery and Evaluation of Duloxetine Therapy
Transcriptomics reveals multiple unexplored pathways and genes altered in the AAK mouse model. Although clinical results with duloxetine are promising, our current regimen and delivery method did not improve established disease. Duloxetine's therapeutic potential requires further study.
Authors
- Arnaud Schweitzer-Chaput (ORCID: https://orcid.org/0000-0002-3558-8997)
- Petros Moustardas (ORCID: https://orcid.org/0000-0003-3192-3708)
- Salvatore Cisternino (ORCID: https://orcid.org/0000-0001-8500-3574)
- Daniel Aberdam (ORCID: https://orcid.org/0000-0002-4019-5418)
- Neil Lagali (ORCID: https://orcid.org/0000-0003-1079-4361)
- Dina Javidjam (ORCID: https://orcid.org/0000-0003-4436-5928)
- Dominique Bremond-Gignac
- Ava Dashti
Institutions
- Linköping University (SE)
- Délégation Paris 5 (FR)
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1167/iovs.67.1.37
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00