The role of non-operative management (NOM) in perforated diverticulitis: a systematic review

Non-operative management (NOM) appears safe and effective for patients with perforated diverticulitis and pericolic extraluminal air, provided there are no clinical signs of generalized peritonitis. In contrast, its role in cases with distant free air is highly uncertain: the pooled success rate is lower, even among hemodynamically stable patients. Based on these findings, early surgical management should be strongly considered for patients with distant free air, while NOM should only be attempted in highly selected cases under strict clinical and radiological monitoring. Conversely, NOM can be confidently recommended for patients with pericolic air who are stable and without diffuse peritonitis.

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Publication Details

Journal
Langenbeck s Archives of Surgery
Published
2026-01-16
DOI
https://doi.org/10.1007/s00423-025-03937-9
Primary Topic
Diverticular Disease and Complications
Type
article
Field-Weighted Citation Impact
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article

The role of non-operative management (NOM) in perforated diverticulitis: a systematic review

Michelangelo Campanale, Matteo Matteucci, Gabrio Bassotti, Riccardo Nascimbeni et al.
Langenbeck s Archives of Surgery
Diverticular Disease and Complications
article

The role of non-operative management (NOM) in perforated diverticulitis: a systematic review

Michelangelo Campanale, Matteo Matteucci, Gabrio Bassotti, Riccardo Nascimbeni, Giulio Mari, Justin Davies, Andrea Mingoli, Mauro Zago, Bruno Cirillo, Gioia Brachini
article en

Abstract

Non-operative management (NOM) appears safe and effective for patients with perforated diverticulitis and pericolic extraluminal air, provided there are no clinical signs of generalized peritonitis. In contrast, its role in cases with distant free air is highly uncertain: the pooled success rate is lower, even among hemodynamically stable patients. Based on these findings, early surgical management should be strongly considered for patients with distant free air, while NOM should only be attempted in highly selected cases under strict clinical and radiological monitoring. Conversely, NOM can be confidently recommended for patients with pericolic air who are stable and without diffuse peritonitis.

Langenbeck s Archives of SurgeryVol. 411(1)
University of Milan (IT), University of Ferrara (IT), University of Perugia (IT), Cambridge University Hospitals NHS Foundation Trust (GB), Alessandro Manzoni Hospital (IT), Presidio Ospedaliero (IT), Addenbrooke's Hospital (GB), University of Brescia (IT), Sapienza University of Rome (IT)
Openalex Percentile: Top 86%
Diverticular Disease and Complications
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