Thonningianin A derived from Penthorum chinense Pursh alleviates cerebral ischemia/reperfusion-mediated apoptosis and pyroptosis through the activation of PINK1/Parkin-dependent mitophagy
This study identifies TA as a novel natural agent alleviating CI/RI by activating PINK1/Parkin-mediated mitophagy, thereby concurrently suppressing apoptosis and pyroptosis. These findings provide the first elucidating the molecular mechanis underlying TA's potential as a therapeutic candidate for IS.
Authors
- Jianmin Wu (ORCID: https://orcid.org/0000-0002-0999-9194)
- Lu Yu
- Anguo Wu (ORCID: https://orcid.org/0000-0002-9850-7576)
- Guishan Hu
- Hong Lin (ORCID: https://orcid.org/0000-0003-2497-2827)
- Qianfang Yao
- Lu Yu
- Can Yin (ORCID: https://orcid.org/0000-0003-1951-9649)
- Xi Du (ORCID: https://orcid.org/0000-0002-4290-5460)
- Dalian Qin
- Xiaogang Zhou
- Jianqiao Li
- Li Chen
Institutions
- Macau University of Science and Technology (MO)
- Southwest Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s13020-025-01247-2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00