Potential Mechanism of Gumibao Decoction in Treating Glucocorticoidinduced Osteoporosis Based on Network Pharmacology and ExperimentalVerification
Gumibao decoction effectively improves glucocorticoid-induced osteoporosis, potentially by upregulating the expression of TGF-β1, P-Smad2/3, and Smad4 through the TGF-Β/Smad pathway, promoting bone formation, and restoring bone metabolic balance in glucocorticoid-induced osteoporosis rats.
Authors
- Guoqiang Liang (ORCID: https://orcid.org/0000-0002-2355-444X)
- Huanhuan Feng (ORCID: https://orcid.org/0000-0001-7856-3485)
- Pengfei Yu (ORCID: https://orcid.org/0000-0003-4702-2648)
- Liang Wang
- Ganqun Lu
- Dong Xiao
- Zhengfeng Gong
Institutions
- Nanjing University of Chinese Medicine (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
- Suzhou Chien-Shiung Institute of Technology (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0113862073388008251008041439
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00