Sex differences in the relationship of biomarker change to memory decline in early Alzheimer’s disease: an observational cohort study
Sex differences in the relationship between AD biomarker levels and cognitive decline vary by disease stage. Although not statistically significant, females demonstrated resilience to memory decline in the preclinical stage, whereas, in the MCI stage, they experienced significantly steeper memory loss compared to males. Results suggest that accounting for sex in biomarker-based methods of disease detection and tracking can improve early detection and intervention in both sexes.
Authors
- Lindsay J. Rotblatt (ORCID: https://orcid.org/0000-0002-2854-577X)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Thomas Hildebrandt
- Anat Biegon
- Maricedes Acosta Martinez
- Sarah J. Banks
Institutions
- Mount Sinai Hospital (US)
- Uppsala University Hospital (SE)
- University of California San Diego (US)
- Stony Brook School (US)
- VA San Diego Healthcare System (US)
- Southern California Clinical and Translational Science Institute (US)
- Stony Brook University (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s13293-025-00820-6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00