Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats

Overall, morphine augments the sepsis-induced depression of reflex cardiovagal activity through an opioid receptor sensitive mechanism that engages brainstem inflammatory and chemotactic circuits related to PI3K/MAPK/NADPHox/ROCK signaling.

Authors

Mona Helmy (ORCID: https://orcid.org/0000-0002-1409-7988)
M. El-Mas Mahmoud
Mohamed Abdelnaby
Rao Ms (ORCID: https://orcid.org/0000-0002-8815-2089)
Marwa Sallam
Hanan M. El-Gowelli

Institutions

Kuwait University (KW)
Alexandria University (EG)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2026-01-16
DOI: https://doi.org/10.3389/fphar.2025.1669284
Primary Topic: Vagus Nerve Stimulation Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats

Mona Helmy, M. El-Mas Mahmoud, Mohamed Abdelnaby, Rao Ms et al.

Jan 16, 2026

Frontiers in Pharmacology

Vagus Nerve Stimulation Research

article

Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats

Mona Helmy, M. El-Mas Mahmoud, Mohamed Abdelnaby, Rao Ms, Marwa Sallam, Hanan M. El-Gowelli

January 16, 2026article en

Abstract

Frontiers in PharmacologyVol. 16

Kuwait University (KW), Alexandria University (EG)

Good health and well-being

Openalex Percentile: Top 89%

Vagus Nerve Stimulation Research

DOI Open Access PDF OpenAlex

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Inflammatory and chemotactic signals of the brainstem solitary tract mediate the morphine exacerbation of impaired reflex chronotropism in septic rats — Mona Helmy, M. El-Mas Mahmoud, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS