Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways
PM<sub>2.5</sub> promotes BC progression through both the MAPK/ERK and Wnt/β-catenin signaling pathways. MEK/ERK inhibition suppressed PM<sub>2.5</sub>-induced nuclear translocation of β-catenin, suggesting that the MAPK/ERK pathway functions upstream of the Wnt/β-catenin pathway. This study provides mechanistic insights into how PM<sub>2.5</sub> exposure drives BC progression and offers a potential foundation for developing targeted therapies for PM<sub>2.5</sub>-associated BC.
Authors
- Hsiu-Ni Kung
- Yung-Ting Cheng
- Shu-Ying Hong
- Kai-Hsi Lu
- Chao-Yuan Huang
- Chung-Hsin Chen
Institutions
- National Taiwan University (TW)
- Cheng Hsin General Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s12989-025-00656-3
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00