An integrative algorithm combining HLA epitope registry, PIRCHE-T2, and PIRCHE-B outcomes to improve immunological risk stratification in kidney transplantation
Integrating Epregistry, PIRCHE-T2, and PIRCHE-B enhances risk stratification for kidney transplant recipients. Epregistry and PIRCHE-B evaluate HLA antibody epitope mismatches, and PIRCHE-T2 focuses on T-cell mismatches. Applied in conjunction, the methods show improved predictive accuracy, making this multi-algorithm approach more effective in identifying high-risk patients. By enabling earlier interventions and personalized immunosuppressive strategies, this model has the potential to improve long-term transplant success.
Authors
- Twyla Pearce
- C W Lewis
- Paul Keown (ORCID: https://orcid.org/0000-0001-6466-8251)
- Karen Sherwood (ORCID: https://orcid.org/0000-0002-3191-7263)
- He Zhao (ORCID: https://orcid.org/0000-0001-5095-1777)
- Destinie Webster
- Matthias Niemann (ORCID: https://orcid.org/0000-0002-3514-9812)
- Pramath Kakodkar (ORCID: https://orcid.org/0000-0002-5288-1247)
- Dan Zhang (ORCID: https://orcid.org/0000-0001-9792-4549)
- Ahmed Shoker
- Fang Wu
- Eric Wang
- Ahmed Mostafa
Institutions
- Roche (Switzerland) (CH)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of British Columbia (CA)
- Saskatchewan Health (CA)
- University of Saskatchewan (CA)
- Beijing Anzhen Hospital (CN)
- Immungenetics (Germany) (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1718506
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00