Material-dependent effects of injectable platelet rich-fibrin on growth factor release, inflammation, and osteoclast activity: an in vitro study
i-PRF showed different synergetic responses based on collagen and calcium phosphate composition in materials it was combined with. Meaning that these findings provide guidance for optimizing biomaterial and i-PRF combinations in surgical applications and inform the design of next-generation PRF-material composites.
Authors
- Lana Micko (ORCID: https://orcid.org/0000-0001-9408-162X)
- Elena Della Bella (ORCID: https://orcid.org/0000-0001-5151-7390)
- Arita Dubņika (ORCID: https://orcid.org/0000-0001-8940-5335)
- Alexander Sieberath (ORCID: https://orcid.org/0000-0002-6676-4164)
- Ilze Šalma
- Lauma Ieviņa
Institutions
- Riga Technical University (LV)
- AO Foundation (CH)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Riga Stradiņš University (LV)
- Baltic Studies Centre (LV)
- LWL-Universitätsklinikum Bochum (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s12903-025-07487-w
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00