Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

By integrating scRNA-seq and scATAC-seq data, this study delineates the heterogeneity of immune cell populations in KD at the single-cell level. The findings highlight coordinated immune and platelet activation pathways that may contribute to KD-associated inflammation and IVIG resistance. These results provide mechanistic insights into KD immunopathogenesis and suggest potential cellular and molecular targets for therapeutic intervention.

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Publication Details

Journal
Frontiers in Molecular Biosciences
Published
2026-01-16
DOI
https://doi.org/10.3389/fmolb.2026.1758948
Primary Topic
Kawasaki Disease and Coronary Complications
Type
article
Field-Weighted Citation Impact
0.00

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article

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

Jinwen Liao, Yuehao Xu, Shuang Deng, Xin Guo et al.
Frontiers in Molecular Biosciences
Kawasaki Disease and Coronary Complications
article

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

Jinwen Liao, Yuehao Xu, Shuang Deng, Xin Guo, Xue Fan, Bin Wang, Mingguo Xu
article en

Abstract

By integrating scRNA-seq and scATAC-seq data, this study delineates the heterogeneity of immune cell populations in KD at the single-cell level. The findings highlight coordinated immune and platelet activation pathways that may contribute to KD-associated inflammation and IVIG resistance. These results provide mechanistic insights into KD immunopathogenesis and suggest potential cellular and molecular targets for therapeutic intervention.

Frontiers in Molecular BiosciencesVol. 13
Shenzhen University (CN), Shantou University (CN), Longgang Central Hospital (CN), Shantou University Medical College (CN), Southern Medical University Shenzhen Hospital (CN), Shenzhen Third People’s Hospital (CN)
National Natural Science Foundation of China, Guangdong Pharmaceutical University
Openalex Percentile: Top 86%
Kawasaki Disease and Coronary Complications
DOIOpen Access PDFOpenAlex
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Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease — Jinwen Liao, Yuehao Xu, et al. · Frontiers in Molecular Biosciences (2026) | TGRS Research Map | TGRS