Predicting the Mechanism of Action of Bawei Chufan Soup in TreatingTeen Depression through Network Pharmacology, Molecular Docking andMolecular Dynamics Simulation

Through network pharmacology, this study preliminarily predicted the material basis and mechanism of action of BWCFS in treating TD. Furthermore, the therapeutic effects of BWCFS on TD may be associated with neuroinflammation and structural and functional changes in neuronal dendrites. The cAMP-PKA-NF-κB and cAMP-PI3K-AKT-NF-κB pathways are proposed as potential therapeutic targets.

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Publication Details

Journal
Current Computer - Aided Drug Design
Published
2026-01-08
DOI
https://doi.org/10.2174/0115734099381670251024040419
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Predicting the Mechanism of Action of Bawei Chufan Soup in TreatingTeen Depression through Network Pharmacology, Molecular Docking andMolecular Dynamics Simulation

Weina Zhu, Huang Huang, Chengcheng Song
Current Computer - Aided Drug Design
Tryptophan and brain disorders
article

Predicting the Mechanism of Action of Bawei Chufan Soup in TreatingTeen Depression through Network Pharmacology, Molecular Docking andMolecular Dynamics Simulation

Weina Zhu, Huang Huang, Chengcheng Song
article en

Abstract

Through network pharmacology, this study preliminarily predicted the material basis and mechanism of action of BWCFS in treating TD. Furthermore, the therapeutic effects of BWCFS on TD may be associated with neuroinflammation and structural and functional changes in neuronal dendrites. The cAMP-PKA-NF-κB and cAMP-PI3K-AKT-NF-κB pathways are proposed as potential therapeutic targets.

Current Computer - Aided Drug DesignVol. 22
Nanjing University of Chinese Medicine (CN), Wenzhou Hospital of Traditional Chinese Medicine (CN)
Good health and well-being
Openalex Percentile: Top 84%
Tryptophan and brain disorders
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