Predicting the Mechanism of Action of Bawei Chufan Soup in TreatingTeen Depression through Network Pharmacology, Molecular Docking andMolecular Dynamics Simulation
Through network pharmacology, this study preliminarily predicted the material basis and mechanism of action of BWCFS in treating TD. Furthermore, the therapeutic effects of BWCFS on TD may be associated with neuroinflammation and structural and functional changes in neuronal dendrites. The cAMP-PKA-NF-κB and cAMP-PI3K-AKT-NF-κB pathways are proposed as potential therapeutic targets.
Authors
- Weina Zhu (ORCID: https://orcid.org/0000-0001-9836-896X)
- Huang Huang (ORCID: https://orcid.org/0000-0002-3944-5635)
- Chengcheng Song
Institutions
- Nanjing University of Chinese Medicine (CN)
- Wenzhou Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Current Computer - Aided Drug Design
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0115734099381670251024040419
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00