Preparation of Dual-Drug-Loaded Liver-Targeted Liposomes Co-Modifiedwith SP94 Peptide and TAT Peptide

SP94/TAT-DOX/DTX-LPs achieved effective dual-stage targeting and synergistic cytotoxicity. High encapsulation, stability, and sustained release support their potential as a targeted platform for liver cancer therapy, reducing off-target toxicity.

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Publication Details

Journal
Current Drug Delivery
Published
2026-01-08
DOI
https://doi.org/10.2174/0115672018371655251022113914
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
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article

Preparation of Dual-Drug-Loaded Liver-Targeted Liposomes Co-Modifiedwith SP94 Peptide and TAT Peptide

Ye Gan, Haotian Wu, Jiankai Zhang, Lili Li et al.
Current Drug Delivery
Nanoparticle-Based Drug Delivery
article

Preparation of Dual-Drug-Loaded Liver-Targeted Liposomes Co-Modifiedwith SP94 Peptide and TAT Peptide

Ye Gan, Haotian Wu, Jiankai Zhang, Lili Li, Xu Liu, Jing Lin, Simei Luo, Mingqing Yuan
article en

Abstract

SP94/TAT-DOX/DTX-LPs achieved effective dual-stage targeting and synergistic cytotoxicity. High encapsulation, stability, and sustained release support their potential as a targeted platform for liver cancer therapy, reducing off-target toxicity.

Current Drug DeliveryVol. 23
Guangxi University (CN), Buchang Pharma (China) (CN)
Good health and well-being
Openalex Percentile: Top 88%
Nanoparticle-Based Drug Delivery
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