PHYTOCHEMICAL ANALYSIS, THERAPEUTIC APPLICATIONS, TABLETFORMULATION OF MORINGA OLEIFERA FOR DISEASE MANAGEMENT

Moringa oleifera Lam., revered as the "miracle tree," has been scientifically validated in this study as a rich source of bioactive compounds with remarkable therapeutic potential. Through advanced GC-MS and HPLC-DAD analyses, we identified quercetin (38.23%), gallic acid (15.62%), and chlorogenic acid (16.76%) as the predominant phytochemicals responsible for its pharmacological effects. The 70% ethanolic extract demonstrated exceptional antioxidant activity (DPPH IC₅₀: 17.5 μg/mL), comparable to ascorbic acid, along with potent antimicrobial action against pathogenic strains like Staphylococcus aureus (MIC: 125 μg/mL) and significant α-glucosidase inhibition (IC₅₀: 0.38 mg/mL), underscoring its antidiabetic properties. Building on these findings, we developed an optimized tablet formulation using gelatin binder that exhibited superior physicochemical characteristics, including optimal hardness (6.3 kg/cm²), low friability (0.31%), and rapid drug release (92.7% in 30 minutes), while maintaining stability under accelerated conditions. This research not only provides a comprehensive phytochemical and pharmacological profile of Moringa oleifera but also delivers a standardized, clinically viable tablet formulation, bridging the gap between traditional medicine and modern therapeutic applications for managing oxidative stress, infections, and metabolic disorders.