B7-H3-targeted natural killer cells effectively kill atypical teratoid / rhabdoid tumors and extend survival in orthotopic xenografts
Anti-B7-H3 CAR-NK cells effectively kill AT/RTs in multiple pre-clinical <i>in vitro</i> and <i>in vivo</i> models in an antigen-specific manner. Evidence of efficacy in translationally relevant models provides support for using B7-H3-targeting CAR-NK cells in high-risk AT/RT patients.
Authors
- Calixto‐Hope G. Lucas (ORCID: https://orcid.org/0000-0002-8347-9592)
- Danielle Jones (ORCID: https://orcid.org/0000-0003-2773-4293)
- Ruyan Rahnama (ORCID: https://orcid.org/0000-0003-3025-3546)
- Challice Lee Bonifant (ORCID: https://orcid.org/0000-0001-9028-1683)
- Stamatia C. Vorri (ORCID: https://orcid.org/0000-0002-6100-1985)
- Megan Zinsky
- Eric H Raabe
- Shramana Guchhait
- Adrianna Amaral
- Sachiv Chakravarti
- Natalie J. Holl
- Tony Choe
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-16
- DOI
- https://doi.org/10.64898/2026.01.15.699746
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alex's Lemonade Stand Foundation for Childhood Cancer
- Johns Hopkins University
- National Cancer Institute