Histone lactylation-derived TET2 enhanced Arg1-mediated MDSC immunosuppression
This research reveals that the histone lactylation-mediated alteration of TET2 presents a novel therapeutic target for cancer treatment.
Authors
- Pengtao Bao
- Wenxin Da
- Yun Dai (ORCID: https://orcid.org/0009-0009-4285-8332)
- W. Zhu
- Jie Ma
- Yan Zhang
- Bo Shen
- Shengjun Wang
- Deqiang Wang
Institutions
- Jiangsu University (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- Institut de Recherche en Santé Digestive (FR)
- Jiangsu Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1677780
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Jiangsu Provincial Key Research and Development Program