TGFβ pathway represses hepatic ribosome biogenesis and protein synthesis by regulating p70S6K–S6RP proteins
Collectively, our data reveal a SMAD-dependent regulatory role of TGFβ-superfamily signaling on hepatocytes that is tightly connected with hepatic growth to ensure proper energy homeostasis and metabolism. This is a critical regeneration parameter, which is closely related to the restoration of hepatic mass, especially following liver injury and fibrosis.
Authors
- Constantinos Stathopoulos (ORCID: https://orcid.org/0000-0002-5699-4118)
- Eleftherios Pavlos
- S Sakellariou
- Vassiliki Stamatopoulou (ORCID: https://orcid.org/0000-0003-4900-5796)
- Maria Manioudaki
- Xilouri Maria
- Athanasios Stavropoulos
Institutions
- University of Crete (GR)
- University of Patras (GR)
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Biomedical Research Foundation of the Academy of Athens (GR)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s11658-025-00853-0
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00