Multi-omics integration and machine learning identify NPC2 as a prognostic and treatment-responsive regulator in lung adenocarcinoma
The comprehensive analysis of multiple omics data significantly enhances the molecular classification of lung adenocarcinoma. Furthermore, AIDPI is a potential biomarker that predicts the prognosis of LUAD patients. NPC2 inhibits the progression of LUAD by suppressing the PI3K/AKT signaling pathway and enhancing the chemotherapy sensitivity to Ribociclib.
Authors
- Jiawei Liu (ORCID: https://orcid.org/0000-0003-1789-9430)
- Ang Li (ORCID: https://orcid.org/0000-0002-8992-3914)
- Ping Cui (ORCID: https://orcid.org/0009-0009-7239-2756)
- Yi Guan (ORCID: https://orcid.org/0000-0002-1944-1610)
- Xianlei Zhou
- Zimo Yan
- Hongmei Zhang
- Wenlong Wu
- Lili Liu
Institutions
- North China University of Science and Technology (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1697560
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44