Exploring the Therapeutic Synergy of Quercetin Gel and Mechanical Debridement in Periimplantitis Management: A Prospective Clinical Evaluation

Introduction: Peri-implantitis is a chronic inflammatory disorder characterized by continuous bone loss around dental implants, endangering their stability and long-term function. While mechanical debridement remains the cornerstone of therapy, emerging evidence supports the enhancement of outcomes through adjunctive agents, including antibiotics, antiseptics, and antioxidants. Aim: To evaluate the adjunctive efficacy of quercetin gel when applied locally alongside non-surgical mechanical debridement in peri-implantitis management. Materials and Methods: The present prospective clinical study was conducted at the Department of Periodontology, Saveetha Dental College and Hospitals, Chennai,Tamil Nadu, India between August and December 2024. Fifty patients diagnosed with peri-implantitis were included and randomly divided into two groups (n=25 each). group 1 (Control) received mechanical debridement alone, while group 2 (Test) received mechanical debridement with subgingival application of 1.2% quercetin hydrogel. Demographic data such as age, and gender were recorded. Clinical parameters including Plaque Index (PI), Gingival Index (GI), Periimplant Probing Depth (PPD), and Clinical Attachment Level (CAL) were assessed at baseline and after three months. Statistical analysis included paired and independent t-tests, with significance set at p<0.05. Results: At baseline, no significant differences were observed between the two groups in terms of age, gender, or clinical parameters (p>0.05). After three months, both groups showed statistically significant improvements in all clinical indices (p<0.05). However, group 2 demonstrated significantly greater reductions in PI (2.57±0.06 to 0.39±0.18), GI (2.55±0.16 to 0.66±0.19), PPD (5.84±0.19 mm to 3.01±0.02 mm), and CAL (6.47±0.11 mm to 3.13±0.12 mm) compared to group 1 (p<0.05 for all intergroup comparisons). Conclusion: Incorporating quercetin gel into standard mechanical debridement protocols yielded enhanced periimplant health outcomes. These findings suggest that quercetin gel may serve as a valuable adjunct in the non-surgical management of Peri-implantitis.