Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models

Aging is the most significant risk factor for Parkinson's disease (PD), yet its role remains underexplored. The International Network for Parkinson's Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.

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Publication Details

Journal
npj Parkinson s Disease
Published
2026-01-16
DOI
https://doi.org/10.1038/s41531-025-01239-x
Citations
1
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
39.15

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article

Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models

Kirsten Harvey, Ilaria Bellantuono, L. J. Niedernhofer, M. Y. Schmidt et al.
1 citations
npj Parkinson s Disease
Parkinson's Disease Mechanisms and Treatments
39.15
article

Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models

Kirsten Harvey, Ilaria Bellantuono, L. J. Niedernhofer, M. Y. Schmidt, D. Ehninger, J. H. J. Hoeijmakers, L. É. Trudeau, A. M. Cuervo, D. Jurk, D. J. Moore, K. L. Double, K. C. Luk, M. S. Goldberg, P. G. Mastroberardino, J. K. Andersen
article en
1 citations

Abstract

Aging is the most significant risk factor for Parkinson's disease (PD), yet its role remains underexplored. The International Network for Parkinson's Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.

npj Parkinson s DiseaseVol. 12(1)
The University of Sydney (AU), Albert Einstein College of Medicine (US), University of Minnesota (US), Van Andel Institute (US), Buck Institute for Research on Aging (US), University of L'Aquila (IT), German Center for Neurodegenerative Diseases (DE), Erasmus MC (NL), University of Alabama at Birmingham (US), Oncode Institute (NL), IFOM (IT), Princess Máxima Center (NL), Mayo Clinic in Florida (US), Erasmus MC Cancer Institute (NL), University Hospital Cologne (DE), Canadian Sleep & Circadian Network (CA), University College London (GB), Université de Montréal (CA), University of Pennsylvania (US), Neuroscience Research Australia (AU), University of Sheffield (GB)
Michael J. Fox Foundation for Parkinson's Research, National Institutes of Health, National Institute on Aging
Partnerships for the goals
Openalex Percentile: Top 1%
Parkinson's Disease Mechanisms and Treatments
39.15
DOIOpen Access PDFOpenAlex
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