Synthesis of Enduracididine Free Linear Teixobactin Analogs:Molecular Docking, DFT Calculations, and Their AntimicrobialActivities, Bacterial Cell Wall Lysis and Glucose Assay
Mass, 1H NMR, and HPLC analysis characterized the synthesized fine TX analogs (TX1-TX5). The DFT and docking studies' electronic characteristic calculations predicted that halogenated (TX1, TX2, and TX4) and methoxy (TX3) substituted analogs have higher stability and electrophilicity, making them suitable agents for antimicrobial activity.
Authors
- Gururaj Kudur Jayaprakash (ORCID: https://orcid.org/0000-0003-0681-7815)
- A. V. Reddy
- Gouthami Kuruvalli
- Trimurthulu Sadhanala
- Nagendra Govindappa
- Kumari Dalli
- Damodara Reddy Vaddi
Institutions
- Meenakshi Academy of Higher Education and Research (IN)
- Natco Pharma (India) (IN)
- REVA University (IN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0109298673382051251001045242
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00