Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: primary results of the ARCHER study
In mild-to-moderate acute myocarditis, treatment with pharmaceutically manufactured cannabidiol was not associated with a statistically significant change in myocardial ECV or GLS, although a trend towards reduction in ECV was observed. In addition, improvement in other potential markers of myocardial recovery, including a significant reduction in LV mass, was seen in the active treatment group. Further investigation of the therapeutic potential of this therapy in inflammatory cardiac conditions is warranted.
Authors
- Étienne Puymirat (ORCID: https://orcid.org/0000-0002-0533-9682)
- Lídia Zytynski Moura (ORCID: https://orcid.org/0000-0002-4741-322X)
- Mark Hofmeyer (ORCID: https://orcid.org/0000-0001-9339-5889)
- Arvind Bhimaraj (ORCID: https://orcid.org/0000-0003-3042-8027)
- Gil Moravsky
- Stuart Pocock (ORCID: https://orcid.org/0000-0003-2212-4007)
- François Roubille (ORCID: https://orcid.org/0000-0002-5288-9687)
- Leslie Cooper
- Georgia Thomas (ORCID: https://orcid.org/0000-0002-8303-258X)
- Matthias G. Friedrich (ORCID: https://orcid.org/0000-0003-1204-5647)
- Ariane Vieira Scarlatelli Macedo (ORCID: https://orcid.org/0000-0002-3453-8488)
- Moreira Mda C
- Paulo Caramori (ORCID: https://orcid.org/0000-0002-7895-8281)
- Pavan Bhat (ORCID: https://orcid.org/0000-0001-8955-1586)
- A. J. Hamer (ORCID: https://orcid.org/0000-0001-6172-8300)
- Artur Haddad Herdy (ORCID: https://orcid.org/0000-0001-9263-5916)
- Fernando Carvalho Neuenschwander (ORCID: https://orcid.org/0000-0001-6387-7924)
- F Huang
- Daniel A. Zlotoff (ORCID: https://orcid.org/0000-0001-9007-7295)
- Andrea B. Parker
- Carsten Tschöpe (ORCID: https://orcid.org/0000-0001-5243-8985)
- Eldon R. Smith
- Peter P. Liu
- Yaron Arbel
- Theo Pezel
- Claire Bouleti
- David Lin
- Edimar Bocch
- Eduardo Dytz
- Benoit Lattuca
- Brittany Palmer
- Xavier Alejandro Piltz
- Luís Beck da Silva
- Mathieu Kerneis
- Jeremie Abtan
- Edimar Bocchi
- ARCHER Study Group
- Guillermo Torre-Amione
- Amir Orlev
- Thomas Bochaton
- W H Wilson Tang
Institutions
- Houston Methodist (US)
- Cleveland Clinic (US)
- University of Ottawa (CA)
- University of Calgary (CA)
- Heidelberg University (DE)
- Tel Aviv Sourasky Medical Center (IL)
- Jacksonville College (US)
- McGill University Health Centre (CA)
- University Hospital Heidelberg (DE)
- Sorbonne Université (FR)
- London School of Hygiene & Tropical Medicine (GB)
- Hospital Zambrano Hellion (MX)
- Deutsches Herzzentrum der Charité (DE)
- Methodist Hospital (US)
- Pitié-Salpêtrière Hospital (FR)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- University of Pittsburgh Medical Center (US)
- Instituto de Cardiologia de Santa Catarina (BR)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Io Therapeutics (United States) (US)
- Chirurgische Universitätsklinik Heidelberg (DE)
- Action Contre la Faim (FR)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1093/eschf/xvaf034
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00