Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure
In patients with chronic HF, lower LDL-C levels were associated with higher mortality, especially in the low ASMI group. These findings suggest that low cholesterol levels may exacerbate skeletal muscle loss, potentially creating a vicious cycle that worsens patient outcomes. Lipid-modulating strategies could help mitigate muscle wasting in HF.
Authors
- Tania Garfias‐Veitl (ORCID: https://orcid.org/0000-0003-3672-4046)
- Ryosuke Sato (ORCID: https://orcid.org/0000-0003-0724-7842)
- Mirela Vatic (ORCID: https://orcid.org/0000-0003-3559-8404)
- Guglielmo Fibbi (ORCID: https://orcid.org/0009-0001-1937-1157)
- Wolfram Doehner
- Stefan D. Anker
- Stephan von Haehling
Institutions
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Deutsches Herzzentrum München (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/jcsm.70168
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission