The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats

CIS therapy accelerates memory deficits in female rats by increasing oxidative stress. However, TRIZ did not alleviate the memory deficits or antioxidant reductions, although it did reduce ROS levels.

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Publication Details

Journal
Frontiers in Toxicology
Published
2026-01-16
DOI
https://doi.org/10.3389/ftox.2026.1752511
Primary Topic
Cancer-related cognitive impairment studies
Type
article
Field-Weighted Citation Impact
0.00

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article

The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats

H. Almutairi, Ahmad Hamad Alhowail
Frontiers in Toxicology
Cancer-related cognitive impairment studies
article

The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats

H. Almutairi, Ahmad Hamad Alhowail
article en

Abstract

CIS therapy accelerates memory deficits in female rats by increasing oxidative stress. However, TRIZ did not alleviate the memory deficits or antioxidant reductions, although it did reduce ROS levels.

Frontiers in ToxicologyVol. 8
Qassim University (SA)
Qassim University
Good health and well-being
Openalex Percentile: Top 87%
Cancer-related cognitive impairment studies
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The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats — H. Almutairi, Ahmad Hamad Alhowail · Frontiers in Toxicology (2026) | TGRS Research Map | TGRS