The radiotherapy induced cyclic GMP-AMP-synthase re-localization and immune signature predicts HNSCC treatment efficacy
These findings suggest that cGAS re-localization and systemic IFN responses may serve as biomarkers for RT efficacy, providing a basis for optimizing HNSCC treatment protocols, especially when integrated with immunotherapy.
Authors
- Gosse J. Adema (ORCID: https://orcid.org/0000-0002-6750-1665)
- Vera Mekers (ORCID: https://orcid.org/0000-0001-6989-7619)
- J KAANDERS
- Vera M. Kho (ORCID: https://orcid.org/0000-0003-3794-012X)
- Marleen Ansems (ORCID: https://orcid.org/0000-0003-0196-5755)
- Paul N. Span (ORCID: https://orcid.org/0000-0002-1930-6638)
- W. L. G. Melchers
- Lune van den Bogaard (ORCID: https://orcid.org/0009-0004-9060-2925)
- Maaike W.G. Looman
- Johan Bussink
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1038/s43856-025-01336-1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00