Multiplex autoantibody screening in pediatric type 1 diabetes: POC Blot vs. ELISA for gluten-related disorders

The POC blot assay demonstrates promising potential as a reliable and rapid screening tool for autoantibodies in pediatric patients with T1D and gluten-related disorders in resource-limited settings. While further validation is needed, these findings suggest that POC testing could facilitate earlier diagnosis and improve the clinical management of coexisting autoimmune conditions in this population.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-16
DOI
https://doi.org/10.3389/fimmu.2025.1648451
Primary Topic
Celiac Disease Research and Management
Type
article
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article

Multiplex autoantibody screening in pediatric type 1 diabetes: POC Blot vs. ELISA for gluten-related disorders

Mesfin Bekele, Patricia Wusterhausen, Adugna Boke Negussie, Torsten Matthias et al.
Frontiers in Immunology
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article

Multiplex autoantibody screening in pediatric type 1 diabetes: POC Blot vs. ELISA for gluten-related disorders

Mesfin Bekele, Patricia Wusterhausen, Adugna Boke Negussie, Torsten Matthias, Demise Mulugeta, Deselegn Muleta
article en

Abstract

The POC blot assay demonstrates promising potential as a reliable and rapid screening tool for autoantibodies in pediatric patients with T1D and gluten-related disorders in resource-limited settings. While further validation is needed, these findings suggest that POC testing could facilitate earlier diagnosis and improve the clinical management of coexisting autoimmune conditions in this population.

Frontiers in ImmunologyVol. 16
College of Medical Sciences (NP), CS Diagnostics (DE), The Medical Device (United Kingdom) (GB), Adama Science and Technology University (ET)
Good health and well-being
Openalex Percentile: Top 88%
Celiac Disease Research and Management
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