Effectiveness and dose stability of opioids in patients with restless leg syndrome: 5-year findings from the National Restless Legs Syndrome Opioid Registry

Opioid doses in augmented RLS remain largely stable over five years of follow-up. Low-dose opioids provide an effective long-term option for augmented RLS.

Authors

John W. Winkelman (ORCID: https://orcid.org/0000-0003-1673-5418)
Justin J. Sherfey
Benjamin Wipper (ORCID: https://orcid.org/0000-0002-3143-5627)
Jordana Zackon
Adysn Kilty

Institutions

Tufts University (US)
Brigham and Women's Hospital (US)
Harvard University (US)
George Washington University (US)
Massachusetts General Hospital (US)

Publication Details

Journal: SLEEP
Published: 2026-01-14
DOI: https://doi.org/10.1093/sleep/zsag008
Primary Topic: Restless Legs Syndrome Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Effectiveness and dose stability of opioids in patients with restless leg syndrome: 5-year findings from the National Restless Legs Syndrome Opioid Registry

John W. Winkelman, Justin J. Sherfey, Benjamin Wipper, Jordana Zackon et al.

Jan 14, 2026

SLEEP

Restless Legs Syndrome Research

article

Effectiveness and dose stability of opioids in patients with restless leg syndrome: 5-year findings from the National Restless Legs Syndrome Opioid Registry

John W. Winkelman, Justin J. Sherfey, Benjamin Wipper, Jordana Zackon, Adysn Kilty

January 14, 2026article en

Abstract

Opioid doses in augmented RLS remain largely stable over five years of follow-up. Low-dose opioids provide an effective long-term option for augmented RLS.

SLEEP

Tufts University (US), Brigham and Women's Hospital (US), Harvard University (US), George Washington University (US), Massachusetts General Hospital (US)

Good health and well-being

Openalex Percentile: Top 86%

Restless Legs Syndrome Research

DOI Source OpenAlex

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Effectiveness and dose stability of opioids in patients with restless leg syndrome: 5-year findings from the National Restless Legs Syndrome Opioid Registry — John W. Winkelman, Justin J. Sherfey, et al. · SLEEP (2026) | TGRS Research Map | TGRS