Characterization and Prognostic Factors of Severe Pediatric Traumatic Brain Injury

This study characterized a significant cohort of children with severe TBI and highlighted the potential prognostic relevance of early clinical and laboratory variables, including GCS, PIM3, lactate, and fibrinogen. While PIM3 remained the only variable independently associated with mortality in exploratory multivariable analysis, GCS, lactate, and fibrinogen demonstrated clinically and biologically relevant associations with mortality in early assessment. Early identification of these factors may guide clinical decisions and therapeutic interventions, as well as have prognostic value, if confirmed in large-scale multicenter studies.