Cold agglutinin syndrome in a patient with metastatic breast cancer: a Case Report

This case illustrates a rare and severe immune complication of paclitaxel in metastatic breast cancer. The emergence of CAS not only limited systemic options but also reshaped the therapeutic trajectory, highlighting the need for close monitoring during cancer treatments. Early recognition, multidisciplinary approach, and prompt management can provide some improvement, although overall prognosis remains determined by the underlying malignancy.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-16
DOI
https://doi.org/10.3389/fmed.2025.1711809
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
0.00

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article

Cold agglutinin syndrome in a patient with metastatic breast cancer: a Case Report

Beatriz Gosálbez, Dina Rochate, Sara Carvalhal, Daniel Bandarra et al.
Frontiers in Medicine
Blood groups and transfusion
article

Cold agglutinin syndrome in a patient with metastatic breast cancer: a Case Report

Beatriz Gosálbez, Dina Rochate, Sara Carvalhal, Daniel Bandarra, J. M. A. Ferreira, Nidia Maltez Cunha
article en

Abstract

This case illustrates a rare and severe immune complication of paclitaxel in metastatic breast cancer. The emergence of CAS not only limited systemic options but also reshaped the therapeutic trajectory, highlighting the need for close monitoring during cancer treatments. Early recognition, multidisciplinary approach, and prompt management can provide some improvement, although overall prognosis remains determined by the underlying malignancy.

Frontiers in MedicineVol. 12
Algarve Biomedical Center (PT), University of Algarve (PT)
Fundação para a Ciência e a Tecnologia
Good health and well-being
Openalex Percentile: Top 88%
Blood groups and transfusion
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Cold agglutinin syndrome in a patient with metastatic breast cancer: a Case Report — Beatriz Gosálbez, Dina Rochate, et al. · Frontiers in Medicine (2026) | TGRS Research Map | TGRS