Clinical and Biological Determinants of Longitudinal Cognitive Function in Patients With <scp> <i>GBA1</i> </scp> Variants and Subthalamic Deep Brain Stimulation
GBA1 variant carriers meeting general STN-DBS indication criteria did not show accelerated cognitive decline in the presence of STN-DBS. In addition, exploratory predictors of dementia could support counseling of DBS candidates. ANN NEUROL 2026;99:976-988.
Authors
- D Weiss
- A. Gharabaghi
- Stefanie Lerche (ORCID: https://orcid.org/0000-0002-5508-004X)
- Idil Cebi (ORCID: https://orcid.org/0000-0002-1458-9173)
- Isabel Wurster (ORCID: https://orcid.org/0000-0003-0157-5722)
- Philipp Klocke (ORCID: https://orcid.org/0000-0003-0868-5270)
- M. Loeffler (ORCID: https://orcid.org/0000-0002-0267-2762)
- Kathrin Brockmann
- Thomas Gasser
Institutions
- Hertie Institute for Clinical Brain Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/ana.78139
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00