Catha edulis and Datura stramonium mitigate oxidative stress, mitochondrial dysfunction, and cell death in an SH-SY5Y model of Parkinson's disease

Both plant extracts preserved cell viability, reduced ROS levels, and maintained mitochondrial integrity, highlighting their potential as therapeutic agents for PD.

Authors

Vanessa Steenkamp (ORCID: https://orcid.org/0000-0003-3575-0410)
W.J. Rudolph
A.D. de Beer
T. Mogale

Institutions

University of Pretoria (ZA)

Publication Details

Journal: Journal of Ethnopharmacology
Published: 2026-01-16
DOI: https://doi.org/10.1016/j.jep.2026.121223
Primary Topic: Parkinson's Disease Mechanisms and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Catha edulis and Datura stramonium mitigate oxidative stress, mitochondrial dysfunction, and cell death in an SH-SY5Y model of Parkinson's disease

Vanessa Steenkamp, W.J. Rudolph, A.D. de Beer, T. Mogale

Jan 16, 2026

Journal of Ethnopharmacology

Parkinson's Disease Mechanisms and Treatments

article

Catha edulis and Datura stramonium mitigate oxidative stress, mitochondrial dysfunction, and cell death in an SH-SY5Y model of Parkinson's disease

Vanessa Steenkamp, W.J. Rudolph, A.D. de Beer, T. Mogale

January 16, 2026article en

Abstract

Both plant extracts preserved cell viability, reduced ROS levels, and maintained mitochondrial integrity, highlighting their potential as therapeutic agents for PD.

Journal of EthnopharmacologyVol. 360

University of Pretoria (ZA)

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Parkinson's Disease Mechanisms and Treatments

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Catha edulis and Datura stramonium mitigate oxidative stress, mitochondrial dysfunction, and cell death in an SH-SY5Y model of Parkinson's disease — Vanessa Steenkamp, W.J. Rudolph, et al. · Journal of Ethnopharmacology (2026) | TGRS Research Map | TGRS