Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review
In an anti-Ro/SSA-positive pregnancy at extreme risk, a prevention-first, protocol-driven approach-centered on hydroxychloroquine, judicious immunomodulation, and structured AV-interval surveillance-successfully averted CAVB and resulted in a pacemaker-free live birth. Minor cardiac lesions warrant ongoing follow-up; however, the absence of conduction disease underscores the clinical utility of this strategy in carefully selected, extreme-risk pregnancies.
Authors
- Shengguang Li (ORCID: https://orcid.org/0000-0003-4623-8607)
- Jing Zhang
- Jianhong Chen
- Xiangyuan Liu
Institutions
- Peking University (CN)
- Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1702173
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00