Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review

In an anti-Ro/SSA-positive pregnancy at extreme risk, a prevention-first, protocol-driven approach-centered on hydroxychloroquine, judicious immunomodulation, and structured AV-interval surveillance-successfully averted CAVB and resulted in a pacemaker-free live birth. Minor cardiac lesions warrant ongoing follow-up; however, the absence of conduction disease underscores the clinical utility of this strategy in carefully selected, extreme-risk pregnancies.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-16
DOI
https://doi.org/10.3389/fimmu.2025.1702173
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
Field-Weighted Citation Impact
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article

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review

Shengguang Li, Jing Zhang, Jianhong Chen, Xiangyuan Liu
Frontiers in Immunology
Systemic Lupus Erythematosus Research
article

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review

Shengguang Li, Jing Zhang, Jianhong Chen, Xiangyuan Liu
article en

Abstract

In an anti-Ro/SSA-positive pregnancy at extreme risk, a prevention-first, protocol-driven approach-centered on hydroxychloroquine, judicious immunomodulation, and structured AV-interval surveillance-successfully averted CAVB and resulted in a pacemaker-free live birth. Minor cardiac lesions warrant ongoing follow-up; however, the absence of conduction disease underscores the clinical utility of this strategy in carefully selected, extreme-risk pregnancies.

Frontiers in ImmunologyVol. 16
Peking University (CN), Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region (CN), Peking University International Hospital (CN)
Good health and well-being
Openalex Percentile: Top 88%
Systemic Lupus Erythematosus Research
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