Multifactorial conceptual model of cancer-related accelerated aging
Evidence suggests that cancer-related accelerated aging contributes to an earlier onset of chronic diseases; persistent symptoms; and decrements in patients' quality of life. This review presents the Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA), a conceptual framework that is grounded in Life Course Theory and supported by empiric evidence. The model includes six inter-related concepts: person, behavioral, biological, treatment, symptom, and life course factors. The MMCRAA can be used by clinicians and researchers to identify patients at increased risk for cancer-related accelerated aging; guide personalized treatment planning; and inform the development of interventions and research.
Authors
- Morse Lh
- Melisa L. Wong (ORCID: https://orcid.org/0000-0001-6390-6959)
- S Weiss
- Thomas K. Hoffmann (ORCID: https://orcid.org/0000-0001-5127-3779)
- Christine S. Ritchie
- Christine Miaskowski
- Margaret Wallhagen
Institutions
- San Francisco VA Medical Center (US)
- United States Department of Veterans Affairs (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Kaiser Permanente Oakland Medical Center (US)
- Massachusetts General Hospital (US)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- npj Aging
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1038/s41514-025-00328-8
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- University of California, San Francisco