Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers
While no causal relationship between MS liability and cancer risk was identified, shared genetic effects highlight potential biological mechanisms linking immune regulation in MS and cancer risk. The observed antagonistic pleiotropy, where genetic variants increase MS risk but decrease cancer susceptibility, mirrors patterns seen in autoimmunity and infection.
Authors
- Philippe Lefrançois (ORCID: https://orcid.org/0000-0003-2939-7956)
- A Manouchehrinia
- Asli Buyukkurt (ORCID: https://orcid.org/0000-0003-2529-4618)
- Ingrid Skelton Kockum (ORCID: https://orcid.org/0000-0002-0867-4726)
- Marius Ygonia
- Adil Harroud
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Jewish General Hospital (CA)
- Karolinska Institutet (SE)
- McGill Genome Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/acn3.70298
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation Brain Canada
- Canadian Bee Research Fund
- Government of Canada
- Azrieli Foundation
- Health Canada
- Fonds de Recherche du Québec - Santé