Assessment for potential bias in multiplexed IL-10 and TNF-α from plex count

While the multiplex assays demonstrated variation at low analyte levels, especially for IL-10, such differences might not substantially affect comparability when mixed with single plex assays, particularly in datasets dominated by low concentrations.

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Publication Details

Journal
Clinical Chemistry and Laboratory Medicine (CCLM)
Published
2026-01-16
DOI
https://doi.org/10.1515/cclm-2025-0458
Primary Topic
Advanced Biosensing Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Assessment for potential bias in multiplexed IL-10 and TNF-α from plex count

Daniel McConnell, Wade M Sanders, Carrie A. Karvonen-Gutierrez
Clinical Chemistry and Laboratory Medicine (CCLM)
Advanced Biosensing Techniques and Applications
article

Assessment for potential bias in multiplexed IL-10 and TNF-α from plex count

Daniel McConnell, Wade M Sanders, Carrie A. Karvonen-Gutierrez
article en

Abstract

While the multiplex assays demonstrated variation at low analyte levels, especially for IL-10, such differences might not substantially affect comparability when mixed with single plex assays, particularly in datasets dominated by low concentrations.

Clinical Chemistry and Laboratory Medicine (CCLM)Vol. 64(4)
University of Michigan (US)
Openalex Percentile: Top 87%
Advanced Biosensing Techniques and Applications
DOIOpen Access PDFOpenAlex
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Assessment for potential bias in multiplexed IL-10 and TNF-α from plex count — Daniel McConnell, Wade M Sanders, et al. · Clinical Chemistry and Laboratory Medicine (CCLM) (2026) | TGRS Research Map | TGRS