Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A <scp>GRADE</scp> ‐Based Network Meta‐Analysis

MBS appears superior in the long term (particularly for higher-efficacy procedures, such as RYGB, SG, SADI, and BPD). EBP, except ESG, was less effective than newer OMM. Semaglutide and tirzepatide showed no inferior short-term results in comparison with MBS.

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Publication Details

Journal
Obesity
Published
2026-01-15
DOI
https://doi.org/10.1002/oby.70083
Primary Topic
Bariatric Surgery and Outcomes
Type
article
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article

Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A GRADE ‐Based Network Meta‐Analysis

Benedetta Ragghianti, Edoardo Mannucci, Ricardo V. Cohen, Giuseppe NAVARRA et al.
Obesity
Bariatric Surgery and Outcomes
article

Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A GRADE ‐Based Network Meta‐Analysis

Benedetta Ragghianti, Edoardo Mannucci, Ricardo V. Cohen, Giuseppe NAVARRA, Luca Busetto, Silvio Buscemi, Paolo Sbraccia, Matteo Monami, Nicola Di Lorenzo, Maurizio De Luca, Amanda Belluzzi, Rocco Barazzoni, Tarissa B. Z. Petry
article en

Abstract

MBS appears superior in the long term (particularly for higher-efficacy procedures, such as RYGB, SG, SADI, and BPD). EBP, except ESG, was less effective than newer OMM. Semaglutide and tirzepatide showed no inferior short-term results in comparison with MBS.

ObesityVol. 34(2)
University of Messina (IT), University of Padua (IT), University of Trieste (IT), Hospital Alemão Oswaldo Cruz (BR), Azienda Ospedaliero-Universitaria Careggi (IT), Policlinico Tor Vergata (IT), Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo (IT), University of Florence (IT), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 87%
Bariatric Surgery and Outcomes
DOIOpen Access PDFOpenAlex
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Efficacy and Safety of Pharmacological, Endoscopic, and Surgical Treatments for Obesity: A <scp>GRADE</scp> ‐Based Network Meta‐Analysis — Benedetta Ragghianti, Edoardo Mannucci, et al. · Obesity (2026) | TGRS Research Map | TGRS