Case Report: Murine typhus complicated by symmetrical peripheral gangrene: first report and diagnostic insights from metagenomic next-generation sequencing
This first reported case of murine typhus complicated by symmetrical peripheral gangrene (SPG) establishes its potential to cause life-threatening multiorgan failure. Metagenomic next-generation sequencing (mNGS) resolved the diagnostic challenge by rapidly identifying <i>Rickettsia typhi</i>, guiding life-saving doxycycline therapy and underscoring its value in severe zoonotic infections.
Authors
- Hezhi Li (ORCID: https://orcid.org/0000-0002-8054-9284)
- Linhui Hu (ORCID: https://orcid.org/0000-0002-1649-6624)
- Z W Zhang
- Hengling Zhu
- Zaiming Feng
- Hengbao Zhu
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Children's Hospital of Zhejiang University (CN)
- Boxing People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1746919
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00