The OurHealth Study: A digital genomic cohort for cardiometabolic risk mechanisms in US South Asians
South Asians experience disproportionately elevated cardiometabolic disease risk yet remain underrepresented in genomic research. The OurHealth Study builds a digital biobank of US South Asian adults, integrating remote surveys, mailed biospecimens for sequencing, and electronic health record sharing to identify genetic and non-genetic drivers of cardiometabolic disease. By pairing remote participation with culturally tailored outreach, OurHealth enhances accessibility, supports granular phenotyping, and addresses logistical barriers to genomic research inclusion.
Authors
- Latha Palaniappan (ORCID: https://orcid.org/0000-0002-1245-665X)
- M. Gulati
- Amit V. Khera (ORCID: https://orcid.org/0000-0001-6535-5839)
- Abha Khandelwal
- Sara Haidermota (ORCID: https://orcid.org/0000-0002-8588-3388)
- Aarushi Bhatnagar (ORCID: https://orcid.org/0009-0004-4699-6779)
- Ravi H. Dave
- Sarah Pitafi (ORCID: https://orcid.org/0000-0003-2245-3492)
- Rishi Madnani
- Bhaavana Oruganty
- Sanchita Singal Parulkar
- Rohan Khera
- Aniruddh P. Patel
- Priyansh Shah
- Kaavya Paruchuri
- Harshil Bhavsar
- Christine Russo
- Namrata Sengupta
- Yamini Levitsky
- Pradeep Natarajan
- Kenneth Rice
- Romit Bhattacharya
- Whitney E. Hornsby
- Nishant Uppal
- Matthew P. Conomos
Institutions
- Broad Institute (US)
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Yale New Haven Hospital (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- University of Washington (US)
- Newton Wellesley Hospital (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- The Bronx Defenders (US)
- Baim Institute for Clinical Research (US)
- Verve Therapeutics (United States) (US)
- Stanford Medicine (US)
- Cedars-Sinai Smidt Heart Institute (US)
- University School (US)
- Center for Systems Biology (US)
- Case Western Reserve University (US)
- World Heart Federation (CH)
Publication Details
- Journal
- npj Digital Medicine
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1038/s41746-025-02335-1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harvard Catalyst
- National Institutes of Health