Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

This study reveals the novel mechanism of YB1's tumor targeting and colonization from the perspective of interaction with tumor vasculature. These findings providing critical theoretical support for the future design of more efficient and safer oncolytic bacterial therapies and lay a foundation for YB1's clinical optimization.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-16
DOI
https://doi.org/10.3389/fimmu.2025.1733164
Primary Topic
Cancer Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

Weiwang Duan, Edwin R. Manuel, Dongmei Cui, Bin Yu et al.
Frontiers in Immunology
Cancer Research and Treatments
article

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

Weiwang Duan, Edwin R. Manuel, Dongmei Cui, Bin Yu, Wei Huang, Lei Shi
article en

Abstract

This study reveals the novel mechanism of YB1's tumor targeting and colonization from the perspective of interaction with tumor vasculature. These findings providing critical theoretical support for the future design of more efficient and safer oncolytic bacterial therapies and lay a foundation for YB1's clinical optimization.

Frontiers in ImmunologyVol. 16
The University of Texas MD Anderson Cancer Center (US), Chinese University of Hong Kong (HK), City of Hope (US), Shenzhen Institutes of Advanced Technology (CN), Viva Biotech (China) (CN), Beckman Research Institute, University of Hong Kong (HK)
National Natural Science Foundation of China, National Institutes of Health, Health and Medical Research Fund, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 87%
Cancer Research and Treatments
DOIOpen Access PDFOpenAlex
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Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting — Weiwang Duan, Edwin R. Manuel, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS