Altered placental expression of neurotransmitter and stress-related molecules in first-episode psychosis during pregnancy: Implications for cytoarchitecture and function
Our results provide novel evidence of distinct placental molecular adaptations in FEP-PW, reflecting heightened maternal stress and disrupted neurohormonal environments. These alterations may contribute to adverse placental function and influence fetal neurodevelopmental trajectories, underscoring the placenta's role as a critical mediator in the maternal-placental-fetal axis in psychiatric disorders. Further research is needed to clarify the functional consequences and explore these molecules as potential biomarkers or therapeutic targets in perinatal psychiatry.
Authors
- Patricia De Castro-Martinez (ORCID: https://orcid.org/0009-0002-8591-6116)
- Melchor Alvarez-Mon (ORCID: https://orcid.org/0000-0001-6599-6169)
- Silvestra Barrena-Blázquez (ORCID: https://orcid.org/0000-0003-2715-1979)
- Diego Liviu Boaru
- Juan A. De León-Luis (ORCID: https://orcid.org/0000-0002-6320-2668)
- Laura López-González (ORCID: https://orcid.org/0009-0005-1023-7639)
- Beatriz García-González
- Diego De León-Oliva
- Isabel Pérez-González
- Julia Buján
- Guillermo Lahera
- Raul Diaz-Pedrero
- Marta Presa
- Natalio García-Honduvilla
- Miguel Ángel Alvarez-Mon
- Miguel A Ortega
- Miguel A Saez
- Óscar Fraile-Martinez
- Coral Bravo
Institutions
- Universidad de Alcalá (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitario Príncipe de Asturias (ES)
Publication Details
- Journal
- Psychoneuroendocrinology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1016/j.psyneuen.2026.107751
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.00