Immune-derived cardiac autonomic signatures: predicting autonomic responses to exercise from B-cell phenotypes
CD21<sup>+</sup>CD11c<sup>+</sup> and CD21<sup>-</sup>CD11c<sup>-</sup> aging B-cell subsets display opposite associations with ANS responsiveness to acute exercise, suggesting immunosenescence-linked autonomic modulation on the neuro-immune axis. Distinct B-cell phenotypes may serve as biomarkers of resilience or fragility in aging, supporting personalized interventions to optimize cardiovascular health in aging individuals.
Authors
- Marcelo Silva Navarrete
- Cristian Andrés Núñez-Espinosa (ORCID: https://orcid.org/0000-0002-9896-7062)
- Matías Castillo-Aguilar (ORCID: https://orcid.org/0000-0001-7291-247X)
- Ginés Viscor
- Lindybeth Sarmiento
- Julieta Sepúlveda
Institutions
- Centro de Investigación y Docencia Económicas (MX)
- Universidad de Magallanes (CL)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fnins.2025.1702281
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agencia Nacional de Investigación y Desarrollo