Identification of a genetic risk factor for metformin-induced vitamin B12 deficiency
The observed genetic association suggests that the rs180122 genotype should be considered a significant risk factor for metformin-induced vitamin B<sub>12</sub> deficiency. While clinical monitoring of serum vitamin B<sub>12</sub> levels in patients on metformin is inconsistently done, this finding highlights the potential clinical utility of targeted monitoring for certain subsets of individuals, including those genetically at high risk.
Authors
- LEWIS A. GREEN
- Campbell Archie I.
- Josephine Li (ORCID: https://orcid.org/0009-0007-5289-1887)
- Shiyu Shu
- R. Pearson Ewan
- C N Palmer
- Qing Pan (ORCID: https://orcid.org/0000-0001-7319-4000)
- C Hayward
- Faye D. Baldwin (ORCID: https://orcid.org/0000-0002-9425-791X)
- Munir Pirmohamed
- Andrea L. Jorgensen
- Daniel F. Carr
- Khaled F. Bedair
- Innocent G. Asiimwe
Institutions
- Broad Institute (US)
- Harvard University (US)
- University of Liverpool (GB)
- George Washington University (US)
- Ninewells Hospital (GB)
- Edinburgh Cancer Research (GB)
- Massachusetts General Hospital (US)
- Cancer Research And Biostatistics (US)
- Institute of Genetics and Cancer (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1007/s00125-025-06655-5
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Scottish Government
- UK Research and Innovation
- Department of Health and Social Care
- Scottish Funding Council
- National Institutes of Health
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases