RAB5C Increases Endothelial Release of VWF by Regulating Vesicle Trafficking
Taken together, our data demonstrate that RAB5C regulates VWF release in part through SNAP29 control of vesicle trafficking in endothelial cells. These findings validate genetic epidemiology data linking RAB5C to VWF levels in humans and provide new insights into the molecular mechanisms regulating VWF exocytosis.
Authors
- Pablo Toledano-Sanz (ORCID: https://orcid.org/0000-0002-8347-2227)
- Nunzio Alcharani (ORCID: https://orcid.org/0000-0002-9477-7712)
- William O. Osburn (ORCID: https://orcid.org/0000-0002-7472-3805)
- Paul S. de Vries (ORCID: https://orcid.org/0000-0003-0964-0111)
- Maria Sabater‐Lleal (ORCID: https://orcid.org/0000-0002-0128-379X)
- Alanna C. Morrison (ORCID: https://orcid.org/0000-0001-6381-4296)
- María Delgado-Marín (ORCID: https://orcid.org/0000-0002-3078-7321)
- Claudia González-Cucharero
- Paula Reventun
- Marios Arvanitis
- Maria Viskadourou
- Alanna C. Morrison
- Nicholas L. Smith
- D. Brian Foster
- Alisa S. Wolberg
- Charles J. Lowenstein
Institutions
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- Universidad de Alcalá (ES)
- University of Washington (US)
- Instituto Cajal (ES)
- Universidad Francisco de Vitoria (ES)
- Johns Hopkins Medicine (US)
- Hospital de Sant Pau (ES)
- VA Office of Research and Development (US)
- The Ohio State University Wexner Medical Center (US)
- Karolinska Institutet (SE)
- Kaiser Permanente Washington Health Research Institute (US)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1161/atvbaha.125.323000
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00