Pharmacodynamic studies of taniborbactam (VNRX-5133) combined with cefepime against β-lactamase–producing Gram-negative bacteria in a neutropenic murine thigh infection model
Taniborbactam restored cefepime's activity against resistant Gram-negative bacteria in a time- and concentration-dependent manner at low and higher cefepime exposures, respectively.
Authors
- Marilena Tsala
- Wendy Kloezen
- Claudia Lagarde
- Anouk E Muller
- Maria Siopi
Institutions
- Radboud University Nijmegen (NL)
- National and Kapodistrian University of Athens (GR)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Medisch Centrum Haaglanden (NL)
- University General Hospital Attikon (GR)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1093/jac/dkaf431
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18