Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging
Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers. Pancreatic cancer is characterized with [<sup>68</sup>Ga]Ga-FAPI-04 and <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) uptake in varying degree. However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging. We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [<sup>68</sup>Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in <sup>18</sup>F-FDG PET/CT images.
Authors
- Mert Mahsuni Sevinç (ORCID: https://orcid.org/0000-0002-5073-9714)
- Ahmet Ertuğrul Öztürk
- Elife Akgün
- Esra Arslan
- Göksel Alçın
Institutions
- University of Health Science (KH)
- Sağlık Bilimleri Üniversitesi (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Molecular Imaging and Radionuclide Therapy
- Published
- 2026-01-15
- DOI
- https://doi.org/10.4274/mirt.galenos.2025.91069
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00