Real-World Outcomes of First-Line Immune-Based Combination Therapies in Bone-Metastatic Clear Cell Renal Cell Carcinoma
ICI-CI and ICI-TKI combinations showed comparable outcomes in BM+ mccRCC. Bone progression and SREs remained frequent and often involved preexisting bone lesions. These findings support early integration of local treatments as well as BTAs, which were independently associated with longer bPFS.
Authors
- Johanna Noel
- M. Bennamoun
- Victor Heurtier (ORCID: https://orcid.org/0000-0001-5292-1117)
- Mathilde Cancel (ORCID: https://orcid.org/0000-0003-1162-214X)
- P. Barthelemy
- Clément Dumont (ORCID: https://orcid.org/0000-0003-0846-3571)
- Édouard Auclin (ORCID: https://orcid.org/0000-0001-7039-4840)
- Olivier Huillard (ORCID: https://orcid.org/0000-0001-9764-0845)
- T. Seisen
- Stéphane Oudard (ORCID: https://orcid.org/0000-0003-0893-285X)
- Matthieu Roulleaux-Dugage
- H. Gauthier
- Fabien Moinard-Butot
- Charlotte Joly
- Alia Harba
- Hamid Lardjani
- Loïc Jaffrelot
- Christophe Tournigand
Institutions
- Université Paris-Est Créteil (FR)
- Institut Gustave Roussy (FR)
- Sorbonne Université (FR)
- Institute Mutualiste Montsouris (FR)
- Hôpital Cochin (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bretonneau (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Pitié-Salpêtrière Hospital (FR)
- Institut Bergonié (FR)
- Hôpital Saint-Louis (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Onco-Urologie Prédictive
Publication Details
- Journal
- Clinical Genitourinary Cancer
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1016/j.clgc.2026.102506
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 36.44