Losartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug
Our findings strongly support a new therapeutic use for losartan in blunting LSCD, which is a consequence associated with numerous corneal inflammatory conditions (e.g. diabetic keratopathy and tear gland insufficiency).
Authors
- Nihal Kaplan (ORCID: https://orcid.org/0000-0002-4552-5201)
- Parisa Foroozandeh (ORCID: https://orcid.org/0000-0002-9526-1814)
- H. Peng
- Robert M. Lavker (ORCID: https://orcid.org/0000-0003-2570-9537)
- Xiaolin Qi
- Stephen D. Miller (ORCID: https://orcid.org/0000-0002-9556-0718)
- Kurt Q. Lu (ORCID: https://orcid.org/0000-0002-8297-433X)
- Dan Xu
- Elif Kayaalp-Nalbant
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1167/iovs.67.1.35
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00