Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives
Age modifies the effects of genetic risk factors in IPF. Rare variants confer greater risk in younger individuals whereas the <i>MUC5B</i> SNP confers greater risk in older individuals. Relatives of FPF patients with rare variants exhibit earlier prevalent disease, which has implications for preclinical disease screening.
Authors
- Matthew D. Moll
- David Zhang (ORCID: https://orcid.org/0000-0003-2382-8460)
- Christine Kim Garcia (ORCID: https://orcid.org/0000-0002-0771-1249)
- Ganesh R. Raghu
- Michael M. Cho
- Atlas Khan
- I Noth
- Fernando J. Martínez (ORCID: https://orcid.org/0000-0002-2412-3182)
- Chen Wang
- Chad Newton
- Krzysztof Kiryluk
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Columbia University Irving Medical Center (US)
- University of Washington Medical Center (US)
- Pulmonary and Allergy Associates (US)
- Department of Veterans Affairs (AU)
- Pulmonary and Critical Care Associates (US)
- University of Virginia (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-15
- DOI
- https://doi.org/10.64898/2026.01.07.25342496
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute