Performance of the Leicester risk assessment and Leicester practice risk scores for assessing the risk of undiagnosed type 2 diabetes or prediabetes in diverse populations: protocol for a systematic review of published validations and updates
This review will identify studies that have implemented, modified or validated the LRA and LPR for the risk of undiagnosed T2DM and NDH in different populations. This will allow summary measures, including level of uncertainty, of model performance to be calculated, making this highly relevant to individuals and stakeholders who recommend and implement these models. Review conclusions will also inform the potential update and recalibration of the models. This will ultimately lead to improved outcomes through earlier diagnosis and management.
Authors
- Louise Haddon (ORCID: https://orcid.org/0000-0001-5015-5121)
- Laura Gray (ORCID: https://orcid.org/0000-0002-7903-5796)
- Kamlesh Khunti
- Joie Ensor
Institutions
- University of Leicester (GB)
- British Heart Foundation (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Diagnostic and Prognostic Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s41512-026-00219-w
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care